During the 1700s, smallpox raged through the American colonies and the Continental Army. Smallpox impacted the Continental Army severely during the Revolutionary War, so much so that George Washington mandated inoculation for all Continental soldiers in 1777. Just fifty-six years earlier, in 1721, Bostonian doctors and clergy introduced the procedure to the American colonies. Without the vision and determination of these early Bostonians in normalizing inoculation, Washington may not have made the decision to mandate inoculation for the Continental Army. Though it was a controversial action, many historians credit the medical mandate with the colonists’ victory in the Revolutionary War and the creation of the United States of America.